Bone metabolism and bone mineral density in adolescent idiopathic scoliosis
نویسندگان
چکیده
Methods Bone mineral density (BMD) of the lumbar spine and bilateral proximal femurs (dual energy x-ray absorptiometry) and bone metabolism markers {bone formation marker: serum bone alkaline phosphatase (BAP); bone resorption marker: serum tartrate-resistant acid phosphatase serum band 5 (TRAP5b)} were measured in 55 consecutive AIS subjects aged 10 to 18 years-old (mean: 15.6+/-1.7). BMD, body mass index (BMI), and age of menarche were compared between subjects with normal and high values of TRAP5b.
منابع مشابه
Relationship between bone density and bone metabolism in adolescent idiopathic scoliosis (AIS)
Methods Using dual–energy X ray absorptiometry and bone metabolism markers (bone formation marker; BAP, bone resorption marker; TRAP5b), the bone mineral density of lumbar and bilateral proximal femurs were studied in 41 AIS patients aged 10 to 20 years old, with a mean of 15.2±5.9 years old. Divided into two groups by levels of bone resorption marker (TRAP5b), BMD, BMI and age of menarche were...
متن کاملMorphological and bone strength indices in girls with adolescent idiopathic scoliosis and their correlations with leptin and soluble leptin receptor
Objective Previous studies suggested that leptin has profound effects on bone metabolism and growth. Abnormal leptin and soluble leptin receptor (sOB-R) levels and their correlation patterns with bone mineral density and trabecular bone micro-architecture were recently found to be distinct in girls with adolescent idiopathic scoliosis (AIS). Structural Model Index (SMI) and data derived from Fi...
متن کاملAssociation between vitamin D serum levels and adolescent idiopathic scoliosis
Background Idiopathic scoliosis (IS) is a deformity of the spine that occurs in up to 4% of children during childhood and adolescence. Idiopathic scoliosis is considered multifactorial, and family history may present several individuals affected. We still cannot determine which curves will worsen and at what rate, but some factors, such as age, growth potential and skeletal maturity have been a...
متن کاملAre Volumetric Bone Mineral Density and Bone Micro-Architecture Associated with Leptin and Soluble Leptin Receptor Levels in Adolescent Idiopathic Scoliosis? – A Case-Control Study
BACKGROUND Adolescent idiopathic scoliosis (AIS) is associated with low bone mineral density (BMD). The underlying etiology and how it may relate to the development of osteopenia remains unknown. Leptin has been postulated as one of the etiologic factors of AIS because of its profound effects on bone metabolism and pubertal growth. Its modulator, soluble leptin receptor (sOB-R), may affect lept...
متن کاملPolymorphism in interleukin-6 gene is associated with bone mineral density in patients with adolescent idiopathic scoliosis.
Low bone mass and osteopenia have been described in the axial and peripheral skeleton of patients with adolescent idiopathic scoliosis (AIS). Recently, many studies have shown that gene polymorphism is related to osteoporosis. However, no studies have linked the association between IL6 gene polymorphism and bone mass in AIS. This study examined the association between bone mass and IL6 gene pol...
متن کامل